Predicting the range of linkage disequilibrium
نویسندگان
چکیده
منابع مشابه
Predicting the range of linkage disequilibrium.
A much pondered question in the Middle Ages was, ‘‘How many angels can dance on the head of a pin?’’ Today, we pose more sensible questions but answers are not necessarily getting easier. A generally accepted strategy in the mapping of a disease gene is to initially apply linkage analysis for an approximate estimate of the location of the trait gene and to subsequently make use of linkage diseq...
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Linkage disequilibrium (LD) is bases of genomic selection, genomic marker imputation, marker assisted selection (MAS), quantitative trait loci (QTL) mapping, parentage testing and whole genome association studies. The Particular alleles at closed loci have a tendency to be co-inherited. In linked loci this pattern leads to association between alleles in population which is known as LD. Two metr...
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In the study of genomic variation, the nonrandom association of alleles has been a valuable tool for understanding population history, correlating disease phenotypes, and mapping genetic structural variation. These associations, termed linkage disequilibrium, have been quantified to great extent in humans over short distances. Linkage disequilibrium between genetically distant sites has garnere...
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Flowering time varies among Arabidopsis accessions. Some of the genes that contribute to this polygenic trait have been localized using quantitative trait loci (QTL) mapping, eventually leading to the identification of genetic variants that contribute to observed differences in flowering time (El-Assal et al., 2001). Despite this and other similar successes with the positional cloning of QTL, t...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2000
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.97.1.2